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Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo.

Abstract

Clinical trials in settings with intermittent or non-existent internet and power connectivity, for example during humanitarian emergencies, present challenges in the synchronisation of data across different sites, in addition to accessing a centralised

Brindle HE Tetsa-Tata D Edwards T Choi EM Kasonia K Aboubacar S Mambula G Kavunga-Membo H Grais R Johnson J Bausch DG Muyembe-Tamfum JJ Ama IS Lees S Watson-Jones D Camacho A Roberts CH
PLOS global public health 2025 ; 5(5); . doi: 10.1371/journal.pgph.0004487. Epub 2025 05 02

Prevalence of hepatitis C virus seropositivity and active infection in a Rohingya refugee population in Cox's Bazar camps, Bangladesh: a cross-sectional study.

Abstract

BACKGROUND: Hepatitis C virus (HCV) infection is a significant public health concern. Limited data have shown unusually high HCV seroprevalence among Rohingya refugees residing in camps in Cox's Bazar, Bangladesh.

Schramm B Ashakin KA Firuz W Hadiuzzaman M Ben-Farhat J Arias-Rodríguez A Rahman A Gupta PS Bhuiyan ATRH Duka M Balkan S Hossain F
The lancet. Gastroenterology & hepatology 2025 Apr 30; . doi: 10.1016/S2468-1253(25)00094-9. Epub 2025 04 30

Fexinidazole as a new oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a prospective, open-label, single-arm, phase 2-3, non-randomised study.

Abstract

BACKGROUND: Rhodesiense human African trypanosomiasis is a neglected disease with epidemic potential that can rapidly become lethal if left untreated.

Matovu E Nyirenda W Eriatu A Alves D Perdrieu C Lemerani M Wamboga C Lejon V Seixas J Signorell A Reymondier A Baudin E Scherrer B Valverde Mordt O
The Lancet. Global health 2025 May ; 13(5); . doi: 10.1016/S2214-109X(25)00016-6. Epub 2025 04 28

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa.

Abstract

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVID-19 present with overlapping symptoms and co-infection can lead to poor outcomes.

Huerga H Gouillou M Ohler L Taremwa IM Akinyi M Lubega A Muyindike WR Bastard M Bossard C Atieno M Muhindo R Casas EC Nakiyingi L Casenghi M Gupta-Wright A Bonnet M Ndlovu Z
PLOS global public health 2025 ; 5(4); . doi: 10.1371/journal.pgph.0004471. Epub 2025 04 23

The aetiologies, mortality, and disability of non-traumatic coma in African children: a systematic review and meta-analysis.

Abstract

BACKGROUND: Non-traumatic coma in African children is a common life-threatening presentation often leading to hospital attendance.

Ray STJ Fuller CE Boubour A Tshimangani T Kafoteka E Muiruri-Liomba A Malenga A Tebulo A Pensulo P Gushu MB Nielsen M Raees M Stockdale E Langton J Birbeck GL Waithira N Bonnett LJ Henrion MY Fink EL Postels DG O'Brien N Page AL Baron E Gordon SB Molyneux E Dondorp A George EC Maitland K Michael BD Solomon T Chimalizeni Y Lalloo DG Moxon CA Taylor T Mallewa M Idro R Seydel K Griffiths MJ
The Lancet. Global health 2025 Apr 22; . doi: 10.1016/S2214-109X(25)00055-5. Epub 2025 04 22

Determinants of attendance in antenatal care clinics in rural settings in Mali and Burkina Faso: a cross-sectional study.

Abstract

BACKGROUND: Since 2016, the World Health Organization (WHO) has recommended a minimum of eight antenatal care (ANC) contacts during pregnancy, replacing the previous recommendation of four focused ANC visits.

Bognini JD Koita K N'takpe JB Bihoun B Dembélé M Coulibaly O Rouamba T Agboraw E Traoré S Scaramuzzi D Worrall E Hill J Kayentao K Tinto H Briand V
BMC pregnancy and childbirth 2025 Apr 14; 25(1); . doi: 10.1186/s12884-025-07568-2. Epub 2025 04 14
Antenatal care Epidemiology Maternal and childbirth Pregnant women West Africa

Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis-experiences from Armenia.

Abstract

Risk factors for baseline bedaquiline (BDQ) resistance, amplification during treatment, and correlations with treatment outcomes are not fully understood.

Ardizzoni E Mulders W De Diego Fuertes M Hayrapetyan A Mirzoyan A Faqirzai J Khachatryan N Oganezova I Varaine F Bastard M Graulus P Meehan CJ Rigouts L de Jong BC Decroo T Hewison C Van Rie A
Antimicrobial agents and chemotherapy 2025 Apr 09; . doi: 10.1128/aac.01839-24. Epub 2025 04 09
Armenia MDR-TB WGS bedaquiline mutations

Evaluation of a decentralised model of care on case isolation and patient outcomes during the 2018-20 Ebola outbreak in the Democratic Republic of the Congo: a retrospective observational study.

Abstract

BACKGROUND: Partway into the 2018-20 Ebola outbreak in the Democratic Republic of the Congo (DR Congo), a new strategy of decentralised care was initiated to address delays in care seeking, improve community acceptance, and reduce the

Barks PM Camacho A Newport T Ribeiro F Ahuka-Mundeke S Kitenge R Nsio J Coulborn RM Grellety E
The Lancet. Global health 2025 Mar 25; . doi: 10.1016/S2214-109X(25)00011-7. Epub 2025 03 25

Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting - a prospective study in Southwestern Uganda.

Abstract

BACKGROUND: In low-resource settings, limited laboratory capacity adds to the burden of central nervous system (CNS) infections in children and spurs overuse of antibiotics.

Rasti R Kumbakumba E Nanjebe D Mlotshwa P Nassejje M Mzee J Businge S Akankwasa G Nyehangane D Gantelius J Boum Y Mårtensson A Mwanga-Amumpaire J Alfvén T Gaudenzi G
BMC infectious diseases 2025 Mar 22; 25(1); . doi: 10.1186/s12879-025-10732-w. Epub 2025 03 22
Central nervous system infections FilmArray Global health Meningitis Molecular diagnostic techniques Paediatrics