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Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.


Nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dTMP, an essential DNA precursor.

Auteurs: Basta T Boum Y Briffotaux J Becker HF Lamarre-Jouenne I Lambry JC Skouloubris S Liebl U Graille M van Tilbeurgh H Myllykallio H
Référence de l'article: Open biology 2012 Oct ; 2(10); 120120. doi: 10.1098/rsob.120120. Epub 2013 07 12
antimicrobial compounds inhibitor screen naphthoquinone thymidylate synthase ThyX

Incidence, risk factors and causes of death in an HIV care programme with a large proportion of injecting drug users.


OBJECTIVES: To identify factors influencing mortality in an HIV programme providing care to large numbers of injecting drug users (IDUs) and patients co-infected with hepatitis C (HCV).

Auteurs: Spillane H Nicholas S Tang Z Szumilin E Balkan S Pujades-Rodriguez M
Référence de l'article: Tropical medicine & international health : TM & IH 2012 Oct ; 17(10); 1255-63. doi: 10.1111/j.1365-3156.2012.03056.x. Epub 2012 08 05
HIV VIH antiretroviral therapy cohort study estudio de cohortes facteur de risque factores de riesgo injecting drug use mortalidad mortality mortalité risk factor terapia antirretroviral thérapie antirétrovirale usage de drogues injectables uso de drogas inyectables étude de cohorte

Sentinel site community surveillance of mortality and nutritional status in southwestern Central African Republic, 2010.


BACKGROUND: During 2010, a community-based, sentinel site prospective surveillance system measured mortality, acute malnutrition prevalence, and the coverage of a Médecins Sans Frontières (MSF) intervention in four sous-préfectures of

Auteurs: Caleo GM Sy AP Balandine S Polonsky J Palma PP Grais RF Checchi F
Référence de l'article: Population health metrics 2012 Sep 04; 10(1); 18. doi: 10.1186/1478-7954-10-18. Epub 2012 09 04

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.


BACKGROUND: Malaria in pregnancy increases the risk of maternal anemia, abortion and low birth weight. Approximately 85.3 million pregnancies occur annually in areas with Plasmodium falciparum transmission.

Auteurs: Tarning J Kloprogge F Piola P Dhorda M Muwanga S Turyakira E Nuengchamnong N Nosten F Day NP White NJ Guerin PJ Lindegardh N
Référence de l'article: Malaria journal 2012 Aug 22; 11(); 293. doi: 10.1186/1475-2875-11-293. Epub 2012 08 22

Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria.


BACKGROUND: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria.

Auteurs: Ramutton T Hendriksen IC Mwanga-Amumpaire J Mtove G Olaosebikan R Tshefu AK Onyamboko MA Karema C Maitland K Gomes E Gesase S Reyburn H Silamut K Chotivanich K Promnares K Fanello CI von Seidlein L Day NP White NJ Dondorp AM Imwong M Woodrow CJ
Référence de l'article: Malaria journal 2012 Aug 16; 11(); 276. doi: 10.1186/1475-2875-11-276. Epub 2012 08 16