Health Emergency and Disaster Risk Management (Health-EDRM) has recently emerged as a critical field for research, policy, and practice as a result of the growing recognition of health as a core dimension in disaster risk management. Global frameworks such as the WHO 13th General Programme of Work (GPW13), the Sendai Framework for Disaster Risk Reduction 2015-2030, the Sustainable Development Goals (SDGs), and the International Health Regulations (IHR) have goals, targets, and indicators that monitor the health impact of disasters and emergencies and resilience in health systems and communities. Policies and actions guided by the best possible evidence are therefore critical for managing the health risks of emergencies and disasters. However, the evidence base in Health-EDRM is very limited, reflecting the overall lack of research in this area. To address this gap, the WHO Thematic Platform for Health EDRM Research Network (Health EDRM RN) set out to develop a reference book about methods to guide Health-EDRM research.