Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children with Suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara, Uganda.

Auteurs: Boum Y Nyehangane D Llosa AE Saliez N Nanjebe D Kemigisha E Charrel RN Baron E Mwanga-Amumpaire J Page AL
Référence de l'article: The Pediatric infectious disease journal 2019 Jun ; 38(6); e131-e133. doi: 10.1097/INF.0000000000002185. Epub 2019 05 22
eng

Abstract

Several decision rules combining clinical and biological parameters have been proposed to distinguish bacterial from aseptic meningitis, but have not been evaluated in Africa. In children hospitalized with suspected central nervous system infections in Uganda, we found that the Bacterial Meningitis Score and Meningitest showed lower performance than in European children, and that a decision rule designed specifically using parameters associated with bacterial meningitis also showed inadequate diagnostic performance for clinical use.