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AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab.

Abstract

BACKGROUND: In low-and-middle-income countries (LMIC), data related to antimicrobial resistance (AMR) are often inconsistently collected.

Ronat JB Natale A Kesteman T Andremont A Elamin W Hardy L Kanapathipillai R Michel J Langendorf C Vandenberg O Naas T Kouassi F
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2021 Apr 28; doi: 10.1016/j.cmi.2021.04.015. Epub 2021 04 28
Antimicrobial resistance Clinical bacteriology laboratory Low-and middle-income countries Mini-lab Médecins Sans Frontières Surveillance

Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study.

Abstract

BACKGROUND: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.

Polonsky JA Ivey M Mazhar KA Rahman Z le Polain de Waroux O Karo B Jalava K Vong S Baidjoe A Diaz J Finger F Habib ZH Halder CE Haskew C Kaiser L Khan AS Sangal L Shirin T Zaki QA Salam A White K
PLoS medicine 2021 Apr 01; 18(4); e1003587. doi: 10.1371/journal.pmed.1003587. Epub 2021 04 01

Impact of systematic early tuberculosis detection using Xpert MTB/RIF Ultra in children with severe pneumonia in high tuberculosis burden countries (TB-Speed pneumonia): a stepped wedge cluster randomized trial.

Abstract

BACKGROUND: In high tuberculosis (TB) burden settings, there is growing evidence that TB is common in children with pneumonia, the leading cause of death in children under 5 years worldwide.

Vessière A Font H Gabillard D Adonis-Koffi L Borand L Chabala C Khosa C Mavale S Moh R Mulenga V Mwanga-Amumpere J Taguebue JV Eang MT Delacourt C Seddon JA Lounnas M Godreuil S Wobudeya E Bonnet M Marcy O
BMC pediatrics 2021 03 20; 21(1); . doi: 10.1186/s12887-021-02576-5. Epub 2021 03 20
Children Nasopharyngeal aspirate Pneumonia Stool Tuberculosis Xpert MTB/RIF ultra

Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system.

Abstract

BACKGROUND: Direct-acting antiviral treatment for hepatitis C virus (HCV) has provided the opportunity for simplified models of care delivered in decentralised settings by non-specialist clinical personnel.

Meiwen Zhang Daniel O’Keefe Jennifer Craig Keo Samley Voeurng Bunreth Pascal Jolivet Suna Balkan Tonia Marquardt Jean-Philippe Dousset Mickael Le Paih
Lancet Gastroenterol Hepatol 2021 Published Online March 18, 2021. doi.org/10.1016/S2468-1253(21)00012-1
Hépatite C Evaluation Cambodge

Community intervention for child tuberculosis active contact investigation and management: study protocol for a parallel cluster randomized controlled trial.

Abstract

BACKGROUND: There are major gaps in the management of pediatric tuberculosis (TB) contact investigation for rapid identification of active tuberculosis and initiation of preventive therapy.

Vasiliu A Eymard-Duvernay S Tchounga B Atwine D de Carvalho E Ouedraogo S Kakinda M Tchendjou P Turyahabwe S Kuate AK Tiendrebeogo G Dodd PJ Graham SM Cohn J Casenghi M Bonnet M
Trials 2021 Mar 02; 22(1); 180. doi: 10.1186/s13063-021-05124-9. Epub 2021 03 02
Cluster randomized controlled trial Community intervention Contact tracing Pediatric tuberculosis Preventive therapy Tuberculosis symptom screening