Publications

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Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis.

Abstract

There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year.

Djaout K Singh V Boum Y Katawera V Becker HF Bush NG Hearnshaw SJ Pritchard JE Bourbon P Madrid PB Maxwell A Mizrahi V Myllykallio H Ekins S
Scientific reports 2016 06 10; 6 27792. doi: 10.1038/srep27792. Epub 2016 06 10

A review of antimicrobial resistance in East Africa.

Abstract

BACKGROUND AND OBJECTIVES: Knowledge of local and regional antimicrobial resistance (AMR) is important for clinical decision making.

Ampaire L Muhindo A Orikiriza P Mwanga-Amumpaire J Bebell L Boum Y
African journal of laboratory medicine 2016 ; 5(1); 432. doi: 10.4102/ajlm.v5i1.432. Epub 2016 09 15

Population-Level Effect of Cholera Vaccine on Displaced Populations, South Sudan, 2014.

Abstract

Following mass population displacements in South Sudan, preventive cholera vaccination campaigns were conducted in displaced persons camps before a 2014 cholera outbreak.

Azman AS Rumunu J Abubakar A West H Ciglenecki I Helderman T Wamala JF Vázquez Ode L Perea W Sack DA Legros D Martin S Lessler J Luquero FJ
Emerging infectious diseases 2016 06 ; 22(6); 1067-70. doi: 10.3201/eid2206.151592. Epub 2018 01 12
South Sudan Vibrio cholerae bacteria cholera diarrhea displaced persons transmission dynamics vaccine vulnerable populations

Diagnostic Accuracy of the Small Membrane Filtration Method for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Prevalence Setting.

Abstract

Sputum acid-fast bacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB).

Boum Y Kim S Orikiriza P Acuña-Villaorduña C Vinhas S Bonnet M Nyehangane D Mwanga-Amumpaire J Fennelly KP Jones-López EC
Journal of clinical microbiology 2016 06 ; 54(6); 1520-1527. doi: 10.1128/JCM.00017-16. Epub 2016 03 30

Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus.

Abstract

Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities.

Dittrich S Tadesse BT Moussy F Chua A Zorzet A Tängdén T Dolinger DL Page AL Crump JA D'Acremont V Bassat Q Lubell Y Newton PN Heinrich N Rodwell TJ González IJ
PloS one 2016 ; 11(8); e0161721. doi: 10.1371/journal.pone.0161721. Epub 2016 08 25
Jindani A Borgulya G de Patiño IW Gonzales T de Fernandes RA Shrestha B Atwine D Bonnet M Burgos M Dubash F Patel N Checkley AM Harrison TS Mitchison D
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016 06 ; 20(6); 832-8. doi: 10.5588/ijtld.15.0577. Epub 2018 02 14

Detection and Quantification of Mycobacterium tuberculosis in the Sputum of Culture-Negative HIV-infected Pulmonary Tuberculosis Suspects: A Proof-of-Concept Study.

Abstract

RATIONALE: Rapid diagnosis of pulmonary tuberculosis (TB) is critical for timely initiation of treatment and interruption of transmission. Yet, despite recent advances, many patients remain undiagnosed.

Madico G Mpeirwe M White L Vinhas S Orr B Orikiriza P Miller NS Gaeddert M Mwanga-Amumpaire J Palaci M Kreiswirth B Straight J Dietze R Boum Y Jones-López EC
PloS one 2016 ; 11(7); e0158371. doi: 10.1371/journal.pone.0158371. Epub 2016 07 08

Closer to 90-90-90. The cascade of care after 10 years of ART scale-up in rural Malawi: a population study.

Abstract

INTRODUCTION: The antiretroviral therapy (ART) programme supported by Médecins Sans Frontières in the rural Malawian district of Chiradzulu was one of the first in sub-Saharan Africa to scale up ART delivery in 2002.

Maman D Chilima B Masiku C Ayouba A Masson S Szumilin E Peeters M Ford N Heinzelmann A Riche B Etard JF
Journal of the International AIDS Society 2016 ; 19(1); 20673. doi: 10.7448/IAS.19.1.20673. Epub 2016 02 15
HIV incidence prevalence viral load

Maternal perception of emotional difficulties of preschool children in rural Niger.

Abstract

Mental health care for infants and young children is often greatly limited in low-resource settings. The purpose of this study was to describe maternal perception of emotional difficulties of preschool children in a rural area of Niger (Maradi).

Marquer C Grais RF Moro MR
Transcultural psychiatry 2016 06 ; 53(3); 330-46. doi: 10.1177/1363461516645046. Epub 2018 02 15
community humanitarian identification perception psychological difficulties qualitative research young children