Publications

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Early prediction of treatment efficacy in second-stage gambiense human African trypanosomiasis.

Abstract

BACKGROUND: Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies.

Priotto G Chappuis F Bastard M Flevaud L Etard JF
PLoS neglected tropical diseases 2012 ; 6(6); e1662. doi: 10.1371/journal.pntd.0001662. Epub 2012 06 05

Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.

Abstract

BACKGROUND: In 2005, the Democratic Republic of Congo (DRC) adopted artesunate and amodiaquine (ASAQ) as first-line anti-malarial treatment.

Espié E Lima A Atua B Dhorda M Flévaud L Sompwe EM Palma Urrutia PP Guerin PJ
Malaria journal 2012 May 25; 11 174. doi: 10.1186/1475-2875-11-174. Epub 2012 05 25

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial.

Abstract

BACKGROUND: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce.

Muehlenbachs A Nabasumba C McGready R Turyakira E Tumwebaze B Dhorda M Nyehangane D Nalusaji A Nosten F Guerin PJ Piola P
Malaria journal 2012 May 03; 11 150. doi: 10.1186/1475-2875-11-150. Epub 2012 05 03

Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial.

Abstract

BACKGROUND: Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.

von Seidlein L Olaosebikan R Hendriksen IC Lee SJ Adedoyin OT Agbenyega T Nguah SB Bojang K Deen JL Evans J Fanello CI Gomes E Pedro AJ Kahabuka C Karema C Kivaya E Maitland K Mokuolu OA Mtove G Mwanga-Amumpaire J Nadjm B Nansumba M Ngum WP Onyamboko MA Reyburn H Sakulthaew T Silamut K Tshefu AK Umulisa N Gesase S Day NP White NJ Dondorp AM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Apr ; 54(8); 1080-90. doi: 10.1093/cid/cis034. Epub 2012 03 12

High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010.

Abstract

In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data.

Sanchez-Padilla E Dlamini T Ascorra A Rüsch-Gerdes S Tefera ZD Calain P de la Tour R Jochims F Richter E Bonnet M
Emerging infectious diseases 2012 Jan ; 18(1); 29-37. doi: 10.3201/eid1801.110850. Epub 2012 05 15