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Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

Abstract

BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.

Ashley EA Pinoges L Turyakira E Dorsey G Checchi F Bukirwa H van den Broek I Zongo I Urruta PP van Herp M Balkan S Taylor WR Olliaro P Guthmann JP
Malaria journal 2008 Aug 09; 7 154. doi: 10.1186/1475-2875-7-154. Epub 2008 08 09

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.

Abstract

BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration.

Lee SJ Stepniewska K Anstey N Ashley E Barnes K Binh TQ D'Alessandro U Day NP de Vries PJ Dorsey G Guthmann JP Mayxay M Newton P Nosten F Olliaro P Osario L Pinoges L Price R Rowland M Smithuis F Taylor R White NJ
Malaria journal 2008 Aug 02; 7 149. doi: 10.1186/1475-2875-7-149. Epub 2008 08 02

The verbosity epidemic.

Grais RF Ashley EA White NJ
Science (New York, N.Y.) 2008 Jun 27; 320(5884); 1718. doi: 10.1126/science.320.5884.1718a. Epub 2008 07 15

Bleach sedimentation: an opportunity to optimize smear microscopy for tuberculosis diagnosis in settings of high prevalence of HIV.

Abstract

BACKGROUND: The purpose of the study was to evaluate the performance and feasibility of tuberculosis diagnosis by sputum microscopy after bleach sedimentation, compared with by conventional direct smear microscopy, in a setting of high

Bonnet M Ramsay A Githui W Gagnidze L Varaine F Guerin PJ
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008 Jun 01; 46(11); 1710-6. doi: 10.1086/587891. Epub 2008 07 21

Immunogenicity of fractional doses of tetravalent a/c/y/w135 meningococcal polysaccharide vaccine: results from a randomized non-inferiority controlled trial in Uganda.

Abstract

BACKGROUND: Neisseria meningitidis serogroup A is the main causative pathogen of meningitis epidemics in sub-Saharan Africa. In recent years, serogroup W135 has also been the cause of epidemics.

Guerin PJ Naess LM Fogg C Rosenqvist E Pinoges L Bajunirwe F Nabasumba C Borrow R Frøholm LO Ghabri S Batwala V Twesigye R Aaberge IS Røttingen JA Piola P Caugant DA
PLoS neglected tropical diseases 2008 ; 2(12); e342. doi: 10.1371/journal.pntd.0000342. Epub 2008 12 02