Publications

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Does one size fit all? Drug resistance and standard treatments: results of six tuberculosis programmes in former Soviet countries.

Abstract

SETTING: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance.

Bonnet M Sizaire V Kebede Y Janin A Doshetov D Mirzoian B Arzumanian A Muminov T Iona E Rigouts L Rüsch-Gerdes S Varaine F
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2005 Oct ; 9(10); 1147-54. doi: . Epub 2006 01 03

Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh.

Abstract

Bangladesh faces growing levels of Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). Alternative antimalarial therapies, particularly combination regimens, need to be considered.

van den Broek IV Maung UA Peters A Liem L Kamal M Rahman M Rahman MR Bangali AM Das S Barends M Faiz AM
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005 Oct ; 99(10); 727-35. doi: 10.1016/j.trstmh.2005.02.007. Epub 2006 01 17

Control of mucocutaneous leishmaniasis, a neglected disease: results of a control programme in Satipo Province, Peru.

Abstract

Mucocutaneous leishmaniasis (MCL) is an important health problem in many rural areas of Latin America, but there are few data on the results of programmatic approaches to control the disease.

Guthmann JP Arlt D Garcia LM Rosales M de Jesus Sanchez J Alvarez E Lonlas S Conte M Bertoletti G Fournier C Huari R Torreele E Llanos-Cuentas A
Tropical medicine & international health : TM & IH 2005 Sep ; 10(9); 856-62. doi: 10.1111/j.1365-3156.2005.01460.x. Epub 2005 10 06

Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study.

Abstract

BACKGROUND: In sub-Saharan Africa in the 1990s, more than 600,000 people had epidemic meningococcal meningitis, of whom 10% died. The current recommended treatment by WHO is short-course long-acting oily chloramphenicol.

Nathan N Borel T Djibo A Evans D Djibo S Corty JF Guillerm M Alberti KP Pinoges L Guerin PJ Legros D
Lancet (London, England) ; 366(9482); 308-13. doi: 10.1016/S0140-6736(05)66792-X. Epub 2005 10 04
Guthmann JP Ampuero J Fortes F van Overmeir C Gaboulaud V Tobback S Dunand J Saraiva N Gillet P Franco J Denoncin A van Herp M Balkan S Dujardin JC D'Alessandro U Legros D
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005 Jul ; 99(7); 485-92. doi: 10.1016/j.trstmh.2004.11.010. Epub 2005 09 22

Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations.

Abstract

Both northern and southern Sudan are deploying artemisinin-based combinations against uncomplicated Plasmodium falciparum malaria (artesunate+sulfadoxine-pyrimethamine [AS+SP] in the north, artesunate+amodiaquine [AS+AQ] in the south).

Hamour S Melaku Y Keus K Wambugu J Atkin S Montgomery J Ford N Hook C Checchi F
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005 Jul ; 99(7); 548-54. doi: 10.1016/j.trstmh.2004.10.003. Epub 2005 09 22

Selection strength and hitchhiking around two anti-malarial resistance genes.

Abstract

Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity.

Nash D Nair S Mayxay M Newton PN Guthmann JP Nosten F Anderson TJ
Proceedings. Biological sciences 2005 Jun 07; 272(1568); 1153-61. doi: 10.1098/rspb.2004.3026. Epub 2005 11 21

Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial.

Abstract

BACKGROUND: The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa.

Piola P Fogg C Bajunirwe F Biraro S Grandesso F Ruzagira E Babigumira J Kigozi I Kiguli J Kyomuhendo J Ferradini L Taylor W Checchi F Guthmann JP
Lancet (London, England) ; 365(9469); 1467-73. doi: 10.1016/S0140-6736(05)66416-1. Epub 2005 05 03
Guthmann JP Sauvageot D De Filippi L Burny ME Brown V
Lancet (London, England) ; 365(9463); 934. doi: 10.1016/S0140-6736(05)71071-0. Epub 2005 04 08