Publications

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ENG

Antiretroviral Therapy Adherence Interruptions Are Associated With Systemic Inflammation Among Ugandans Who Achieved Viral Suppression.

Abstract

BACKGROUND: Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression.

Auteurs: Musinguzi N Castillo-Mancilla J Morrow M Byakwaga H Mawhinney S Burdo TH Boum Y Muzoora C Bwana BM Siedner MJ Martin JN Hunt PW Bangsberg DR Haberer JE
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2019 Dec 01; 82(4); 386-391. doi: 10.1097/QAI.0000000000002148. Epub 2019 11 01
ENG

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.

Abstract

BACKGROUND: Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.

Auteurs: Mulangu S Dodd LE Davey RT Tshiani Mbaya O Proschan M Mukadi D Lusakibanza Manzo M Nzolo D Tshomba Oloma A Ibanda A Ali R Coulibaly S Levine AC Grais R Diaz J Lane HC Muyembe-Tamfum JJ Sivahera B Camara M Kojan R Walker R Dighero-Kemp B Cao H Mukumbayi P Mbala-Kingebeni P Ahuka S Albert S Bonnett T Crozier I Duvenhage M Proffitt C Teitelbaum M Moench T Aboulhab J Barrett K Cahill K Cone K Eckes R Hensley L Herpin B Higgs E Ledgerwood J Pierson J Smolskis M Sow Y Tierney J Sivapalasingam S Holman W Gettinger N Vallée D Nordwall J
Référence de l'article: The New England journal of medicine 2019 Nov 27; (); Array. doi: 10.1056/NEJMoa1910993. Epub 2019 11 27
ENG

Culture conversion at six months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis.

Abstract

Delamanid should be effective against highly resistant strains of M. tuberculosis, but uptake has been slow globally.

Auteurs: Seung KJ Khan P Franke MF Ahmed S Aiylchiev S Alam M Putri FA Bastard M Docteur W Gottlieb G Hewison C Islam S Khachatryan N Kotrikadze T Khan U Kumsa A Lecca L Tassew YM Melikyan N Naing YY Oyewusi L Rich M Wanjala S Yedilbayev A Huerga H Mitnick CD
Référence de l'article: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Nov 02; (); Array. doi: 10.1093/cid/ciz1084. Epub 2019 11 02
antitubercular agents delamanid extensively drug-resistant tuberculosis multidrug-resistant tuberculosis
ENG

Distribution of advanced HIV disease from three high HIV prevalence settings in Sub-Saharan Africa: a secondary analysis data from three population-based cross-sectional surveys in Eshowe (South Africa), Ndhiwa (Kenya) and Chiradzulu (Malawi).

Abstract

: Despite substantial progress in antiretroviral therapy (ART) scale up, some people living with HIV (PLHIV) continue to present with advanced HIV disease, contributing to ongoing HIV-related morbidity and mortality.: We aimed to quantify population-le

Auteurs: Chihana ML Huerga H Van Cutsem G Ellman T Goemaere E Wanjala S Masiku C Szumilin E Etard JF Maman D Davies MA
Référence de l'article: Global health action 2019 ; 12(1); 1679472. doi: 10.1080/16549716.2019.1679472. Epub 2019 11 04
ART Africa CD4 HIV population-level
ENG

Adherence and population pharmacokinetic properties of amodiaquine when used for seasonal malaria chemoprevention in African children.

Abstract

Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC.

Auteurs: Ding J Coldiron ME Assao B Guindo O Blessborn D Winterberg M Grais RF Koscalova A Langendorf C Tarning J
Référence de l'article: Clinical pharmacology and therapeutics 2019 Oct 25; (); Array. doi: 10.1002/cpt.1707. Epub 2019 10 25
ENG

Should urine-LAM tests be used in TB symptomatic HIV-positive patients when no CD4 count is available? A prospective observational cohort study from Malawi.

Abstract

BACKGROUND: Current eligibility criteria for urine lateral-flow-lipoarabinomannan assay (LF-LAM) in ambulatory, HIV-positive patients rely on the CD4 count.

Auteurs: Huerga H Mathabire Rucker SC Bastard M Dimba A Kamba C Amoros I Szumilin E
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2019 Oct 16; (); Array. doi: 10.1097/QAI.0000000000002206. Epub 2019 10 16
ENG

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda.

Abstract

Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries.

Auteurs: Ardizzoni E Orikiriza P Ssuuna C Nyehangane D Gumsboga M Taremwa IM Turyashemererwa E Mwanga-Amumpaire J Langendorf C Bonnet M
Référence de l'article: Journal of clinical microbiology 2019 Oct 16; (); Array. doi: 10.1128/JCM.00810-19. Epub 2019 10 16
ENG

Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea.

Abstract

BACKGROUND: Alongside the clinical aspects of the immunogenicity and safety trial of an Ebola vaccine deployed among front-line workers, a qualitative study was conducted to describe motivations behind individuals' decisions to partici

Auteurs: Grantz KH Claudot P Kambala M Kouyaté M Soumah A Boum Y Juan-Giner A Jemmy JP Cummings DAT Grais RF
Référence de l'article: Vaccine 2019 Oct 14; (); Array. doi: 10.1016/j.vaccine.2019.09.094. Epub 2019 10 14
Ebola virus disease Guinea Healthcare workers Qualitative Research design rVSV vaccine
ENG

Hand hygiene compliance and environmental contamination with gram-negative bacilli in a rural hospital in Madarounfa, Niger.

Abstract

BACKGROUND: Healthcare-associated infections pose a major, yet often preventable risk to patient safety.

Auteurs: Tang K Berthé F Nackers F Hanson K Mambula C Langendorf C Marquer C Isanaka S
Référence de l'article: Transactions of the Royal Society of Tropical Medicine and Hygiene 2019 Oct 14; (); Array. doi: 10.1093/trstmh/trz070. Epub 2019 10 14
Niger gram-negative bacilli hand hygiene healthcare personnel healthcare-associated infections
ENG

What is the best culture conversion prognostic marker for patients treated for multidrug-resistant tuberculosis?

Abstract

Identification of good prognostic marker for tuberculosis (TB) treatment response is a necessary step on the path towards a surrogate marker to reduce TB trial duration.

Auteurs: Bastard M Sanchez-Padilla E Hayrapetyan A Kimenye K Khurkhumal S Dlamini T Fadul Perez S Telnov A Hewison C Varaine F Bonnet M
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Oct 01; 23(10); 1060-1067. doi: 10.5588/ijtld.18.0649. Epub 2019 10 19