Publications

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Rapid Decision Algorithm for Patient Triage during Ebola Outbreaks.

Abstract

The low specificity of Ebola virus disease clinical signs increases the risk for nosocomial transmission to patients and healthcare workers during outbreaks.

Ardiet DL Nsio J Komanda G Coulborn RM Grellety E Grandesso F Kitenge R Ngwanga DL Matady B Manangama G Mossoko M Ngwama JK Mbala P Luquero F Porten K Ahuka-Mundeke S
Emerging infectious diseases 2024 Nov ; 30(11); . doi: 10.3201/eid3011.231650. Epub 2024 10 24
Algorithm Democratic Republic of the Congo Ebola clinical signs contact epidemics exposure outbreaks predictors symptomatology symptoms triage

Safety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan.

Abstract

BACKGROUND: Epidemic forms of hepatitis E cause high mortality among pregnant people, with case fatality risks over 30% and adverse fetal outcomes.

Nesbitt RC Azman AS Asilaza VK Edwards JK Gitahi P Nkemenang P Duncker J Haile M Gakima P Wamala JF Loro FB Biem D Staderini N Albela M Rull M Rumunu J Ciglenecki I Gignoux E
The Lancet. Global health 2024 Nov ; 12(11); . doi: 10.1016/S2214-109X(24)00321-8. Epub 2024 10 18

External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB.

Abstract

BACKGROUND: Chest X-ray (CXR) misinterpretation negatively affects the accuracy of childhood TB diagnosis. External quality assurance (EQA) could strengthen CXR reading skills.

Melingui BF Leroy-Terquem E Taguebue JV Eap TC Borand L Khosa C Moh R Mwanga-Amumpaire J Beneteau S Eang MT Manhiça I Mustapha A Marcy O Wobudeya E Norval PY Bonnet M
IJTLD open 2024 Oct ; 1(10); . doi: 10.5588/ijtldopen.24.0328. Epub 2024 10 01
chest X-ray children diagnosis external quality assurance limited-resources countries tuberculosis

Oral cholera vaccine coverage in Goma, Democratic Republic of the Congo, 2022, following 2019-2020 targeted preventative mass campaigns.

Abstract

BACKGROUND: In 2019-2020, preventative Oral Cholera Vaccine campaigns were conducted in 24/32 non-contiguous health areas of Goma, DR Congo.

Briskin E Bateyi Mustafa SH Mahamba R Kabunga D Kubuya J Porten K Akilimali L Okitayemba Welo P Broban A
Vaccine: X 2024 Oct ; 20; . doi: 10.1016/j.jvacx.2024.100555. Epub 2024 09 12
Cholera Democratic Republic of the Congo Oral cholera vaccine Targeted vaccination Vaccine coverage survey

Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women.

Abstract

BACKGROUND: Malaria and HIV infection overlap geographically in sub-Saharan Africa and share risk factors. HIV infection increases malaria's severity, especially in pregnant women.

Pons-Duran C Wassenaar MJ Yovo KE Marín-Carballo C Briand V González R
The Cochrane database of systematic reviews 2024 Sep 26; 9; . doi: 10.1002/14651858.CD006689.pub3. Epub 2024 09 26

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.

Abstract

BACKGROUND: Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention.

Schilling WHK Mukaka M Callery JJ Llewelyn MJ Cruz CV Dhorda M Ngernseng T Waithira N Ekkapongpisit M Watson JA Chandna A Nelwan EJ Hamers RL Etyang A Beg MA Sow S Yavo W Allabi AC Basnyat B Sharma SK Amofa-Sekyi M Yonga P Adler A Yuentrakul P Cope T Thaipadungpanit J Rienpradub P Imwong M Abdad MY Blacksell SD Tarning J Goudjo FF Dossou AD Konaté-Touré A Assi SB Ouffoué K Nasronudin N Rachman BE Romadhon PZ Dewanto DD Heryana MO Novi T Pasaribu AP Mutiara M Nasution MPR Khairunnisa K Dalimunthe FA Airlangga E Fahrezzy A Subronto Y Ananda NR Rahardjani M Rimainar A Lucinde RK Timbwa M Onyango OE Agutu C Akech S Hamaluba M Kipyego J Ngachi O Haidara FC Traoré OY Diarra F Khanal B Dahal P Shrestha S Rijal S Kabore Y Adehossi E Guindo O Qamar FN Kazi AM Woodrow CJ Laird S Cheeba M Ayles H Cheah PY Taylor WRJ Batty EM Chotivanich K Pukrittayakamee S Phumratanaprapin W von Seidlein L Dondorp A Day NPJ White NJ
PLoS medicine 2024 Sep ; 21(9); . doi: 10.1371/journal.pmed.1004428. Epub 2024 09 12

Impact of a multi-pronged cholera intervention in an endemic setting.

Abstract

Cholera is a bacterial water-borne diarrheal disease transmitted via the fecal-oral route that causes high morbidity in sub-Saharan Africa and Asia. It is preventable with vaccination, and Water, Sanitation, and Hygiene (WASH) improvements.

Blake A Walder A Hanks E Welo PO Luquero F Bompangue D Bharti N
medRxiv : the preprint server for health sciences 2024 Sep 09; . doi: 10.1101/2023.12.14.23299970. Epub 2024 09 09

Prevalence and Factors Associated with transfusion-transmissible infections among blood donors in Arua regional blood bank, Uganda.

Abstract

BACKGROUND: Blood transfusion services play a very key role in modern health care service delivery. About 118.5 million blood donations were collected globally in 2022.

Cwinyaai N Opio D Kajumbula H Zalwango JF Akunzirwe R Okello T Francis A
BMC infectious diseases 2024 Sep 06; 24(1); . doi: 10.1186/s12879-024-09838-4. Epub 2024 09 06
Blood donor Seropositive blood donor Transfusion-transmissible infections (TTIs) Voluntary donor

Evaluation of centralised and decentralised models of care during the 2020 Ebola Virus Disease outbreak in Equateur Province, Democratic Republic of the Congo: A brief report.

Abstract

BACKGROUND: Traditionally in the Democratic Republic of the Congo (DRC), centralised Ebola treatment centres (ETCs) have been set exclusively for Ebola virus disease (EVD) case management during outbreaks.

Lampaert E Nsio Mbeta J Nair D Mashako M De Weggheleire A Sprecher A M Coulborn R Ahuka-Mundeke S
F1000Research 2024 ; 13; . doi: 10.12688/f1000research.150755.2. Epub 2024 08 28
Central Africa Decentralized care Ebola Epidemic response Operational Research Outbreak SORT IT Viral Haemorrhagic Fever

Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda.

Abstract

BACKGROUND: Deaths occurring during the neonatal period contribute close to half of under-five mortality rate (U5MR); over 80% of these deaths occur in low- and middle-income countries (LMICs).

Mwanga-Amumpaire J Adong J Arinaitwe R Nanjebe D Orikiriza P Ngonzi J Boum Y Bebell LM
BMC pregnancy and childbirth 2024 Aug 27; 24(1); . doi: 10.1186/s12884-024-06775-7. Epub 2024 08 27
Africa Mother Neonate Outcome Pregnancy