Publications
Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests.
Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring mutation, common in southern Africa. In addition, Xpert MTB/RIF does not distinguish between viable and dead (MTB).
Urgently seeking efficiency and sustainability of clinical trials in global health.
This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series.
The role and challenges of cluster randomised trials for global health.
Evaluating whether an intervention works when trialled in groups of individuals can pose complex challenges for clinical research.
Randomised trials at the level of the individual.
In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design.
AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab.
BACKGROUND: In low-and-middle-income countries (LMIC), data related to antimicrobial resistance (AMR) are often inconsistently collected.
Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study.
BACKGROUND: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.
High prevalence of NRTI and NNRTI drug resistance among ART-experienced, hospitalized inpatients.
BACKGROUND: Patients hospitalized with advanced HIV have a high mortality risk.