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Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.

Abstract

BACKGROUND: In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate

Taylor WR Naw HK Maitland K Williams TN Kapulu M D'Alessandro U Berkley JA Bejon P Okebe J Achan J Amambua AN Affara M Nwakanma D van Geertruyden JP Mavoko M Lutumba P Matangila J Brasseur P Piola P Randremanana R Lasry E Fanello C Onyamboko M Schramm B Yah Z Jones J Fairhurst RM Diakite M Malenga G Molyneux M Rwagacondo C Obonyo C Gadisa E Aseffa A Loolpapit M Henry MC Dorsey G John C Sirima SB Barnes KI Kremsner P Day NP White NJ Mukaka M
BMC medicine 2018 01 18; 16(1); 11. doi: 10.1186/s12916-017-0990-6. Epub 2018 01 18
Age-based dosing Malaria Plasmodium falciparum Primaquine Transmission blocking

High rates of hypertension, diabetes, elevated low-density lipoprotein cholesterol, and cardiovascular disease risk factors in HIV-infected patients in Malawi.

Abstract

OBJECTIVES: Data on cardiovascular disease risks among HIV-infected patients taking antiretroviral therapy (ART) over long periods of time are lacking in Sub-Saharan Africa.

Mathabire Rücker SC Tayea A Bitilinyu-Bangoh J Bermúdez-Aza EH Salumu L Quiles IA Szumilin E Chirwa Z Rick F Maman D
AIDS (London, England) 2018 Jan 14; 32(2); 253-260. doi: 10.1097/QAD.0000000000001700. Epub 2018 07 16

Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda.

Abstract

Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings.

Kassaza K Operario DJ Nyehangane D Coffey KC Namugosa M Turkheimer L Ojuka P Orikiriza P Mwanga-Amumpaire J Byarugaba F Bazira J Guler JL Moore CC Boum Y
Journal of clinical microbiology 2018 01 ; 56(1); doi: 10.1128/JCM.01060-17. Epub 2017 12 26
PCR diagnostics high-resolution melting malaria

What's coming for health science and policy in 2018? Global experts look ahead in their field.

Abstract

In PLOS Medicine's first editorial of 2018, editorial board members and other leading researchers share their hopes, pleas, concerns, and expectations for this year in health research and policy.

Swaminathan S Room RS Ivers LC Hillis G Grais RF Bhutta ZA Byass P
PLoS medicine 2018 01 ; 15(1); e1002498. doi: 10.1371/journal.pmed.1002498. Epub 2018 01 30

Dried Blood Spots for Measuring Vibrio cholerae-specific Immune Responses.

Abstract

BACKGROUND: Vibrio cholerae causes over 2 million cases of cholera and 90,000 deaths each year.

Iyer AS Azman AS Bouhenia M Deng LO Anderson CP Graves M Kováč P Xu P Ryan ET Harris JB Sack DA Luquero FJ Leung DT
PLoS neglected tropical diseases 2018 01 ; 12(1); e0006196. doi: 10.1371/journal.pntd.0006196. Epub 2018 01 29

Four years of case-based surveillance of meningitis following the introduction of MenAfriVac in Moissala, Chad: lessons learned.

Abstract

OBJECTIVE: Case-based surveillance of bacterial meningitis in sentinel districts has been recommended after the introduction of the conjugated vaccine against Neisseria meningitidis serogroup A (NmA), MenAfriVac, in the African meningi

Page AL Coldiron ME Gamougam K Acyl MA Tamadji M Lastrucci C Hurtado N Tehoua FC Fermon F Caugant DA Porten K
Tropical medicine & international health : TM & IH 2017 12 ; 22(12); 1561-1568. doi: 10.1111/tmi.12987. Epub 2017 10 26
Chad Tchad bacterial meningitis latex agglutination tests meningococcal meningitis méningite bactérienne méningite pneumococcique méningite à méningocoques pneumococcal meningitis surveillance test d'agglutination au latex

Seasonal malaria chemoprevention: successes and missed opportunities.

Abstract

Seasonal malaria chemoprevention (SMC) was recommended in 2012 for young children in the Sahel during the peak malaria transmission season.

Coldiron ME Von Seidlein L Grais RF
Malaria journal 2017 11 28; 16(1); 481. doi: 10.1186/s12936-017-2132-1. Epub 2017 11 28
Antimalarials Chemoprevention Malaria

Higher risk sexual behaviour is associated with unawareness of HIV-positivity and lack of viral suppression - implications for Treatment as Prevention.

Abstract

Efficacy of Treatment as Prevention Strategy depends on a variety of factors including individuals' likelihood to test and initiate treatment, viral load and sexual behaviour.

Huerga H Venables E Ben-Farhat J van Cutsem G Ellman T Kenyon C
Scientific reports 2017 Nov 23; 7(1); 16117. doi: 10.1038/s41598-017-16382-6. Epub 2017 11 23