Publications

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Adapting to the global shortage of cholera vaccines: targeted single dose cholera vaccine in response to an outbreak in South Sudan.

Abstract

Shortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive vaccination campaigns.

Parker LA Rumunu J Jamet C Kenyi Y Lino RL Wamala JF Mpairwe AM Ciglenecki I Luquero FJ Azman AS Cabrol JC
The Lancet. Infectious diseases 2017 04 ; 17(4); e123-e127. doi: 10.1016/S1473-3099(16)30472-8. Epub 2017 01 19

Towards more accurate HIV testing in sub-Saharan Africa: a multi-site evaluation of HIV RDTs and risk factors for false positives.

Abstract

INTRODUCTION: Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues.

Kosack CS Page AL Beelaert G Benson T Savane A Ng'ang'a A Andre B Zahinda JB Shanks L Fransen K
Journal of the International AIDS Society 2017 03 24; 19(1); 21345. doi: 10.7448/IAS.20.1.21345. Epub 2017 08 30
HIV RDT diagnostic false positive test

Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger.

Abstract

BACKGROUND: Each year, rotavirus gastroenteritis is responsible for about 37% of deaths from diarrhea among children younger than 5 years of age worldwide, with a disproportionate effect in sub-Saharan Africa.

Isanaka S Guindo O Langendorf C Matar Seck A Plikaytis BD Sayinzoga-Makombe N McNeal MM Meyer N Adehossi E Djibo A Jochum B Grais RF
The New England journal of medicine 2017 03 23; 376(12); 1121-1130. doi: 10.1056/NEJMoa1609462. Epub 2017 04 28

Prevalence and correlates of MRSA and MSSA nasal carriage at a Ugandan regional referral hospital.

Abstract

Background: Despite increasing antimicrobial resistance globally, data are lacking on prevalence and factors associated with Staphylococcus aureus (SA) and MRSA carriage in resource-limited settings.

Bebell LM Ayebare A Boum Y Siedner MJ Bazira J Schiff SJ Metlay JP Bangsberg DR Ttendo S Firth PG
The Journal of antimicrobial chemotherapy 2017 03 01; 72(3); 888-892. doi: 10.1093/jac/dkw472. Epub 2017 10 10

Mortality and clinical outcomes in children treated with antiretroviral therapy in four African vertical programmes during the first decade of paediatric HIV care, 2001-2010.

Abstract

OBJECTIVE: To assess mortality and clinical outcomes in children treated with antiretroviral therapy (ART) in four African vertical programmes between 2001 and 2010.

Ben-Farhat J Schramm B Nicolay N Wanjala S Szumilin E Balkan S Pujades-Rodríguez M
Tropical medicine & international health : TM & IH 2017 03 ; 22(3); 340-350. doi: 10.1111/tmi.12830. Epub 2017 01 26

HIV
antiretroviral therapy cohort studies mortality paediatrics treatment failure

Using simulation to aid trial design: Ring-vaccination trials.

Abstract

BACKGROUND: The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines.

Hitchings MD Grais RF Lipsitch M
PLoS neglected tropical diseases 2017 03 ; 11(3); e0005470. doi: 10.1371/journal.pntd.0005470. Epub 2017 03 22

Outcomes from the first multidrug-resistant tuberculosis programme in Kenya.

Abstract

SETTING: In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya.

OBJECTIVE: To describe patients' treatment outcomes and adverse events.

Huerga H Bastard M Kamene M Wanjala S Arnold A Oucho N Chikwanha I Varaine F
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 03 01; 21(3); 314-319. doi: 10.5588/ijtld.16.0661. Epub 2018 02 22

Spatial and temporal dynamics of superspreading events in the 2014-2015 West Africa Ebola epidemic.

Abstract

The unprecedented scale of the Ebola outbreak in Western Africa (2014-2015) has prompted an explosion of efforts to understand the transmission dynamics of the virus and to analyze the performance of possible containment strategies.

Lau MS Dalziel BD Funk S McClelland A Tiffany A Riley S Metcalf CJ Grenfell BT
Proceedings of the National Academy of Sciences of the United States of America 2017 02 28; 114(9); 2337-2342. doi: 10.1073/pnas.1614595114. Epub 2017 02 13
Bayesian inference Ebola offspring distribution superspreading

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).

Abstract

BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus.

Henao-Restrepo AM Camacho A Longini IM Watson CH Edmunds WJ Egger M Carroll MW Dean NE Diatta I Doumbia M Draguez B Duraffour S Enwere G Grais R Gunther S Gsell PS Hossmann S Watle SV Kondé MK Kéïta S Kone S Kuisma E Levine MM Mandal S Mauget T Norheim G Riveros X Soumah A Trelle S Vicari AS Røttingen JA Kieny MP
Lancet (London, England) 2017 02 04; 389(10068); 505-518. doi: 10.1016/S0140-6736(16)32621-6. Epub 2016 12 23

[Trauma and resilience among children 3 to 6 years old in three neighborhoods of Port-au-Prince after the 2010 earthquake in Haiti].

Abstract

The paper describes an action research for indicative assessment of psychological problems of young children following the 2010 earthquake in Haiti, and the interest of using the Creole version of the questionnaire PSYCa 3-6.

Mouchenik Y Dauriac-Le Masson V Marquer C Marty-Chevreuil A Georges R Derivois D Moro MR
L'Encephale 2017 Feb ; 43(1); 27-31. doi: 10.1016/j.encep.2016.04.002. Epub 2016 05 21
Children Earthquake Enfant Haiti Haïti PSYCa 3-6 Psychological screening Séisme Évaluation psychologique