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Community intervention for child tuberculosis active contact investigation and management: study protocol for a parallel cluster randomized controlled trial.

Abstract

BACKGROUND: There are major gaps in the management of pediatric tuberculosis (TB) contact investigation for rapid identification of active tuberculosis and initiation of preventive therapy.

Vasiliu A Eymard-Duvernay S Tchounga B Atwine D de Carvalho E Ouedraogo S Kakinda M Tchendjou P Turyahabwe S Kuate AK Tiendrebeogo G Dodd PJ Graham SM Cohn J Casenghi M Bonnet M
Trials 2021 Mar 02; 22(1); 180. doi: 10.1186/s13063-021-05124-9. Epub 2021 03 02
Cluster randomized controlled trial Community intervention Contact tracing Pediatric tuberculosis Preventive therapy Tuberculosis symptom screening

Improving estimates of the burden of severe wasting: analysis of secondary prevalence and incidence data from 352 sites.

Abstract

INTRODUCTION: Estimates of incident cases of severe wasting among young children are not available for most settings but are needed for optimal planning of treatment programmes and burden estimation.

Isanaka S Andersen CT Cousens S Myatt M Briend A Krasevec J Hayashi C Mayberry A Mwirigi L Guerrero S
BMJ global health 2021 03 ; 6(3); doi: 10.1136/bmjgh-2020-004342. Epub 2021 06 24
child health epidemiology nutrition

Hepatitis C viraemic and seroprevalence and risk factors for positivity in Northwest Cambodia: a household cross-sectional serosurvey.

Abstract

BACKGROUND: Despite a dramatic reduction in HCV drug costs and simplified models of care, many countries lack important information on prevalence and risk factors to structure effective HCV services.

Lynch E Falq G Sun C Bunchhoeung PDT Huerga H Loarec A Dousset JP Marquardt T Paih ML Maman D
BMC infectious diseases 2021 Feb 26; 21(1); 223. doi: 10.1186/s12879-021-05826-0. Epub 2021 02 26
Cambodia HCV Hepatitis C MSF Sero-prevalence Serosurvey Viraemia

Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern uganda by high-resolution melt analysis.

Abstract

BACKGROUND: Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt).

Kassaza K Long AC McDaniels JM Andre M Fredrickson W Nyehangane D Orikiriza P Operario DJ Bazira J Mwanga-Amumpaire JA Moore CC Guler JL Boum Y
Malaria journal 2021 Feb 25; 20(1); 114. doi: 10.1186/s12936-021-03657-7. Epub 2021 02 25
Chloroquine HRM Plasmodium falciparum Resistance Uganda pfcrt

Emergency department admission and hospitalization for COPD exacerbation and particulate matter short-term exposure in Brescia, a highly polluted town in northern Italy.

Abstract

BACKGROUND: Short-term exposure to high Particulate Matter (PM) concentrations worsens several respiratory conditions.

Pini L Giordani J Gardini G Concoreggi C Pini A Perger E Vizzardi E Di Bona D Cappelli C Ciarfaglia M Tantucci C
Respiratory medicine 2021 Feb 16; 179 106334. doi: 10.1016/j.rmed.2021.106334. Epub 2021 02 16

Novel transdisciplinary methodology for cross-sectional analysis of snakebite epidemiology at national scale.

Abstract

BACKGROUND: Worldwide, it is estimated that snakes bite 4.5-5.4 million people annually, 2.7 million of which are envenomed, and 81,000-138,000 die.

Alcoba G Ochoa C Babo Martins S Ruiz de Castañeda R Bolon I Wanda F Comte E Subedi M Shah B Ghimire A Gignoux E Luquero F Nkwescheu AS Sharma SK Chappuis F Ray N
PLoS neglected tropical diseases 2021 Feb 12; 15(2); e0009023. doi: 10.1371/journal.pntd.0009023. Epub 2021 02 12

Seroprevalence and risk factors of exposure to COVID-19 in homeless people in Paris, France: a cross-sectional study.

Abstract

BACKGROUND: During the COVID-19 lockdown period from March 17 to May 11, 2020, French authorities in Paris and its suburbs relocated people experiencing recurrent homelessness to emergency shelters, hotels, and large venues.

Roederer T Mollo B Vincent C Nikolay B Llosa AE Nesbitt R Vanhomwegen J Rose T Goyard S Anna F Torre C Fourrey E Simons E Hennequin W Mills C Luquero FJ
The Lancet. Public health 2021 Feb 05; doi: 10.1016/S2468-2667(21)00001-3. Epub 2021 02 05

Estimation of the correlates of protection of the rVSVΔG-ZEBOV-GP Zaire ebolavirus vaccine: a post-hoc analysis of data from phase 2/3 clinical trials.

Abstract

BACKGROUND: Establishment of immune correlates of protection can provide a measurable criterion for assessing protection against infection or disease.

Rebecca F Grais Stephen B Kennedy Barbara E Mahon Sheri A Dubey ebecca J Grant-Klein R Ken Liu Jonathan Hartzel Beth-Ann Coller Carolee Welebob Mary E Hanson Jakub K Simon
Lancet Microbe 2021;2: e70–78;doi.org/10.1016/S2666-5247(20)30198-1
Vaccination Ebola Clinical trial

Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe.

Abstract

We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB).

Melikyan N Huerga H Atshemyan H Kirakosyan O Sargsyants N Aydinyan T Saribekyan N Khachatryan N Oganezova I Falcao J Balkan S Hewison C
Open forum infectious diseases 2021 Feb ; 8(2); ofaa653. doi: 10.1093/ofid/ofaa653. Epub 2021 01 04
chronic hepatitis C direct-acting antiviral drugs multidrug-resistant tuberculosis sofosbuvir virus