Publications

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Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis.

Abstract

BACKGROUND: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent r

Malaria journal 2019 Jul 05; 18(1); 225. doi: 10.1186/s12936-019-2837-4. Epub 2019 07 05
Competing risk event Plasmodium falciparum Treatment efficacy study

Effectiveness of oral cholera vaccine in preventing cholera among fishermen in Lake Chilwa, Malawi: A case-control study.

Abstract

BACKGROUND: In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability.

Grandesso F Kasambara W Page AL Debes AK M'bang'ombe M Palomares A Lechevalier P Pezzoli L Alley I Salumu L Msyamboza K Sack D Cohuet S Luquero FJ
Vaccine 2019 Jun 19; 37(28); 3668-3676. doi: 10.1016/j.vaccine.2019.05.044. Epub 2019 05 24
Cholera Effectiveness Hard-to-reach populations Malawi Thermostability Vaccine

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria.

Abstract

Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs.

Chotsiri P Denoeud-Ndam L Baudin E Guindo O Diawara H Attaher O Smit M Guerin PJ Doumbo OK Wiesner L Barnes KI Hoglund RM Dicko A Etard JF Tarning J
Clinical pharmacology and therapeutics 2019 Jun 01; doi: 10.1002/cpt.1531. Epub 2019 06 01
Lumefantrine malaria malnutrition non-linear mixed effects modelling population pharmacokinetic-pharmacodynamic model severe acute malnutrition children

Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children with Suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara, Uganda.

Abstract

Several decision rules combining clinical and biological parameters have been proposed to distinguish bacterial from aseptic meningitis, but have not been evaluated in Africa.

Boum Y Nyehangane D Llosa AE Saliez N Nanjebe D Kemigisha E Charrel RN Baron E Mwanga-Amumpaire J Page AL
The Pediatric infectious disease journal 2019 Jun ; 38(6); e131-e133. doi: 10.1097/INF.0000000000002185. Epub 2019 05 22

Cost-effectiveness of community-based screening and treatment of moderate acute malnutrition in Mali.

Abstract

Introduction: Moderate acute malnutrition (MAM) causes substantial child morbidity and mortality, accounting for 4.4% of deaths and 6.0% of disability-adjusted life years (DALY) lost among children under 5 each year.

Isanaka S Barnhart DA McDonald CM Ackatia-Armah RS Kupka R Doumbia S Brown KH Menzies NA
BMJ global health 2019 ; 4(2); e001227. doi: 10.1136/bmjgh-2018-001227. Epub 2019 04 28
CSB++ Mali PlumpySup Super Cereal corn soy blend cost cost-effectiveness moderate acute malnutrition ready to use supplementary foods

Delayed second dose of oral cholera vaccine administered before high-risk period for cholera transmission: Cholera control strategy in Lusaka, 2016.

Abstract

BACKGROUND: In April 2016, an emergency vaccination campaign using one dose of Oral Cholera Vaccine (OCV) was organized in response to a cholera outbreak that started in Lusaka in February 2016.

Ferreras E Matapo B Chizema-Kawesha E Chewe O Mzyece H Blake A Moonde L Zulu G Poncin M Sinyange N Kasese-Chanda N Phiri C Malama K Mukonka V Cohuet S Uzzeni F Ciglenecki I Danovaro-Holliday MC Luquero FJ Pezzoli L
PloS one 2019 ; 14(8); e0219040. doi: 10.1371/journal.pone.0219040. Epub 2019 08 30

Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions: a multisite study.

Abstract

: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB). : To assess the feasibility of using LAM to diagnose TB in adult HIV-positive patients in resource-limited settings.

Mathabire Rucker SC Cossa L Harrison RE Mpunga J Lobo S Kisaka Kimupelenge P Mandar Kol'Ampwe F Amoros Quiles I Molfino L Szumilin E Telnov O Ndlovu Z Huerga H
Global health action 2019 ; 12(1); 1672366. doi: 10.1080/16549716.2019.1672366. Epub 2019 10 15
Lipoarabinomannan diagnosis implementation low income settings tuberculosis

Who is telling the story? A systematic review of authorship for infectious disease research conducted in Africa, 1980-2016.

Abstract

Introduction: Africa contributes little to the biomedical literature despite its high burden of infectious diseases. Global health research partnerships aimed at addressing Africa-endemic disease may be polarised.

Mbaye R Gebeyehu R Hossmann S Mbarga N Bih-Neh E Eteki L Thelma OA Oyerinde A Kiti G Mburu Y Haberer J Siedner M Okeke I Boum Y
BMJ global health 2019 ; 4(5); e001855. doi: 10.1136/bmjgh-2019-001855. Epub 2019 10 18
HIV buruli ulcer clinical trial epidemiology tuberculosis