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Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial.

Abstract

BACKGROUND: Pre-extensively drug-resistant (pre-XDR) tuberculosis (ie, multidrug-resistant or rifampicin-resistant with additional resistance to any fluoroquinolone) is difficult to treat.

Guglielmetti L Khan U Velásquez GE Gouillou M Ali MH Amjad S Kamal F Abubakirov A Ardizzoni E Baudin E Bektassov S Berry C Bonnet M Chavan V Coutisson S Dakenova Z de Jong BC Dinh LV Ferlazzo G Kirakosyan O Lachenal N Lecca L McIlleron H Mikanda KK Mucching-Toscano S Mulders W Mushtaque H Nahid P Nguyen DV Nguyen NV Oyewusi L Motta I Panda S Patil S Pham TH Phan DT Phan HTT Phillips PPJ Ruiz J Rupasinghe P Salahuddin N Sanchez-Garavito E Seung KJ Asfaw MT Vargas Vasquez D Rich ML Varaine F Mitnick CD
The Lancet. Respiratory medicine 2025 Jul 16; . doi: 10.1016/S2213-2600(25)00194-8. Epub 2025 07 16

Diagnostic criteria for severe acute malnutrition and fatal outcomes in children aged 6-59 months, Nigeria.

Abstract

OBJECTIVE: To determine factors associated with inpatient death among a cohort of children aged 6-59 months with severe acute malnutrition in north-western Nigeria.

Grellety E Simons E Mousset M Roederer T Amakade-Woyengba AP Malwal S Adebayo OJ Guais B Lacharité MO Manangama G Nass NS
Bulletin of the World Health Organization 2025 Jul 01; 103(7); . doi: 10.2471/BLT.24.292143. Epub 2025 06 10

High mortality and violence among refugees and returnees from West Darfur, Sudan arriving in Chad, 2023: results from three retrospective mortality surveys.

Abstract

INTRODUCTION: Fighting erupted on 15 April 2023 in Sudan between the army and the paramilitary Rapid Support Forces. By September 2023, more than 420 000 people had fled to Chad.

Simons E Ouedraogo P Garnier C Nicolet C Sayyad-Hilario J Villet E Mahamoud AA Tubiana J Grellety E
BMJ global health 2025 Jun 27; 10(6); . doi: 10.1136/bmjgh-2024-016668. Epub 2025 06 27
Cross-sectional survey Epidemiology Global Health Public Health

Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study.

Abstract

BACKGROUND: WHO recommends Xpert MTB/RIF Ultra (Ultra) for stool testing for tuberculosis diagnosis in children.

Lounnas M Masama EN Beneteau S Kasakwa K Kaitano R Nabeta P Ruhwald M De Haas P Tiemersma EW Nduna B Nicol MP Eyangoh S Wobudeya E Mwanga-Amumpaire J Chabala C Marcy O Bonnet M
The Lancet. Microbe 2025 Jun 23; . doi: 10.1016/j.lanmic.2024.101055. Epub 2025 06 23

Intense rainfalls and floods reshape malaria transmission in Niger.

Abstract

PROBLEM CONSIDERED: The Sahel covers a vast semi-arid area characterized by a long dry season of about 8-9 months and a short rainy season of 3-4 months.

Djedanem M Sale NM Aminou EYYM Descroix L Testa J Jambou R
Acta tropica 2025 Jun 15; 268; . doi: 10.1016/j.actatropica.2025.107699. Epub 2025 06 15
Climate change Flood Land-use Malaria Sahel

Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis.

Abstract

BACKGROUND: International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the concern about fluid overload, but evidence to support this concern is lacking

Maitland K Ouattara SM Sainna H Chara A Ogundipe OF Sunyoto T Hamaluba M Olupot-Olupot P Alaroker F Connon R Saidou Maguina A Okiror W Amorut D Mwajombo E Oguda E Mogaka C Langendorf C Dewez JE Ciglenecki I Gibb DM Coldiron ME Petrucci R George EC
The New England journal of medicine 2025 Jun 13; . doi: 10.1056/NEJMoa2505752. Epub 2025 06 13

Contribution of Maternal Adherence to the Effect of Multiple Micronutrient Supplementation During Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis.

Abstract

Multiple micronutrient supplements (MMSs) in pregnancy reduces risk of infant low birthweight (LBW) and improves other maternal and infant outcomes compared with iron and folic acid (IFA) supplements alone.

Smith ER Gomes F Adu-Afarwuah S Aguayo VM El Arifeen S Bhutta ZA Caniglia EC Christian P Devakumar D Dewey KG Fawzi WW Friis H Gomo E Guindo O Hallamaa L Isanaka S Kæstel P Lachat C Maleta K Moore SE Oakley EM Osrin D Rahman A Rana Z Rizvi A Roberfroid D Shaikh S Sonko B Soofi SB Subarkah I Sunawang R Wang D West KP Wu LSF Zagre N Bourassa MW Sudfeld CR
Advances in nutrition (Bethesda, Md.) 2025 May 30; . doi: 10.1016/j.advnut.2025.100455. Epub 2025 05 30
antenatal care individual participant data meta-analysis multiple micronutrient supplements pregnancy

Sequelae following an epidemic of meningococcal meningitis in Niger in 2022.

Abstract

BACKGROUND: The management of post-meningitis sequelae is a priority in the WHO Roadmap to Defeat Meningitis by 2030.

Idrissa AA Atti S Wasaulua RK Kazadi S Sani O Tassiou EI Guindo O Tonamou G Ciglenecki I Coldiron ME
PloS one 2025 ; 20(5); . doi: 10.1371/journal.pone.0323223. Epub 2025 05 22

Burden of Malaria in Adults in Sahelian Niger: A Retrospective Study (2019-2021).

Abstract

In the Sahel, malaria transmission is highly dependent on rainfall, and control efforts are conducted during the rainy season.

Aminou EYYM Djedanem M Ramatoulaye L Al Moustapha W Hamidou Leyo I Testa J Jambou R
The American journal of tropical medicine and hygiene 2025 May 20; . doi: 10.4269/ajtmh.24-0613. Epub 2025 05 20